Bone MetastasesBone is the third most common site of metastatic disease Cancers most likely to metastasise to bone:
Carcinomas are much more likely to metastasise to bone than sarcomas The axial skeleton is seeded more than the appendicular skeleton, partly due to the persistence of red bone marrow in the former The ribs, pelvis and spine are usually first affected Batson's vertebral venous plexus allows cells to enter the vertebral circulation without first passing through the lungs. The sluggish blood flow in this plexus is more conducive to tumour survival, accounting for the high rate of prostate cancer metastasis to the spine. Pain, pathological fractures and hypercalcemia are the major sources of morbidity with bone metastasis Pain is the most common symptom found in 70% of patients with bone metastases. Pain is caused by stretching of the periosteum by the tumour as well as nerve stimulation in the endosteum This is a preview of the site content. To view the full text for this site, you need to log in. If you are having problems logging in, please refer to the login help page. |
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