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Dupuytren's Disease

Dupuytren was born in central France. He was kidnapped as a boy by a rich woman from Toulouse on account of his good looks. He was taken to Paris and educated, but endured great poverty throughout his studies. Dupuytren became Surgeon in chief at the Hotel Dieu in Paris and worked tremendously hard and became very rich. He was described as an unpleasant person to met, yet his work was delightful to read. He was characterised as "First among surgeons, Last among men". He was an accurate clinical observer with a great interest in pathology. Dupuytren's name is most associated with the contracture of palmar fascia and a particular ankle fracture that he described. He performed his first palmar fasciotomy on a coachman at the Hotel Dieu in 1831. He wrote on many subjects, including congenital dislocation of the hip, the nature of callus formation, subungal exostosis, the Trendelenburg sign, tenotomy in torticollis and he differentiated osteosarcoma from "spina ventosa". He insisted that on his death that his post-mortem be performed in front of his own medical staff and published in the local weekly journal.


25% of males over 65yrs.

Associated with:

  1. Anglo-Saxons
  2. Family history - autosomal dominant; 68% prevelance in first-degree relatives
  3. epileptics (42%)
  4. alcohol-induced liver disease
  5. diabetes mellitus
  6. COAD
  7. hypertension
  8. IHD

Similar fibromatosis lesions found with Dupuytren's: 

  1. Garrods knuckle pads
  2. Ledderhose Disease (plantar fibromatosis), - 5%
  3. Peyronie's disease (penis) - 3%

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