Orthoteers homepage Advertise on Orthoteers
Orthoteers Junior Orthoteers Orthopaedic Biomechanics Orthopaedic World Literature Society Educational Resources Image Gallery About Orthoteers Orthoteers Members search

Genitic disorders


Very basic genetics
  • Genetic abnormalities can be inherited or mutations
  • 46 chromosomes, 22 pairs of autosomes + 2 sex chromosomes. Male XY, female XX.
  • Pair of genes in same place on autosomes = alleles.
  • Incomplete penetrance = can cause skipped generations, genotype present but no expression
  • Variable expressivity = some disorders affect several systems to varying degrees in different individuals

.MENDELIAN DISORDERS

  • = Involve a single gene.

Autosomal dominant

Autosomal Recessive

X linked dominant

  • Either sex can be affected
  • Females pass to 50% sons & Pass to 50% daughters
  • Male pass to 100% of daughters, not to sons
  • eg. 

X linked recessive

Variable forms of Inheritance




This is a preview of the site content. To view the full text for this site, you need to log in.
If you are having problems logging in, please refer to the login help page.


© 2005-2007 Orthoteers.co.uk - last updated by Len Funk on 14 February 2005Medical Merketing and SEO by Blue Medical 
Biomet supporting orthoteersThe British Orthopedic Association supporting OrthoteersOrthoteers is a non-profit educational resource. Click here for more details
About
Anatomy Atlas
Basic sciences
Classifications
Clinical Examination
Courses
Elbow
Extras
Foot and Ankle
FRCS(Tr&Orth) Exam
Glossary
Hand & Wrist
Help
Hip & Pelvis
Humerus
Imaging in Orthopaedics
Knee
Log Book
MCQ
News
Newsletters
Orthopaedic infections & Microbiology
Orthopaedic pathology
Paediatric orthopaedics
Perioperative issues
Rehabilitation
Shoulder
Spine
Statistics
Surgical approaches
Trauma
Home
Hide Menu